• Alias                                 (According to NCBI)

• LDH-M,
• LDH1,
• PIG19
• proliferation-inducing gene 19 protein

• Description   

  (According to SwissProt)

• The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. [provided by RefSeq]

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 11p15.4
• Size: 13283 bp
• exons:
• DNA sequence (Human): NC_000011

• CGH (11p15.4):  Losses (%) -12.3   Gain (%)  2.8  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD : LDHA
• SNPs: 3939

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):NM_005566  

• Size: 1661 bp

• cDNA libraries: LDHA

• Protein                        (According to SwissProt, , PDB, dbPTM)

• Size: 332 amino acids; 36689 Da
• Catalytic activity: (S)-lactate + NAD(+) = pyruvate + NADH.

• Subcellular location: Cytoplasm

• Protein domains

     

• Protein sequence (Human): P00338

• Homologous genes:  56495

• 2D PAGE: LDHA

• 3D Structure:  1I10

• PTM: LDHA

• Pathways and interactions (According to BioCarta, KEGG IntAct)

• Pathway:

         kegg Glycolysis/Gluconeogenesis

         kegg Cysteine metabolism

         kegg Pyruvate metabolism

         kegg Propanoate metabolism

         biocarta Hypoxia-inducible factor in cardiovascular system

         biocarta The SARS-coronavirus life cycle           

• Protein interactions: LDHA

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA):  CAB015336

• Clinical                            (According to OMIM, PubMed)

• OMIM : 150000
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy