• Alias                                 (According to NCBI)

• LDH-H, TRG-5

• Description   

  (According to SwissProt)

• The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. [provided by RefSeq]

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 12p12.2-p12.1
• Size: 22501 bp
• exons: 7
• DNA sequence (Human): NC_000012.10

• CGH (12p12.2):  Losses (%) -5.0   Gain (%)  7.3  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD :
• SNPs: 3945

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human): NM_002300.4

• Size: 1332 bp

• cDNA libraries: LDHB

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 334 amino acids; 36638 Da
• Catalytic activity: (S)-lactate + NAD⁺ = pyruvate + NADH.

• Subcellular location: Cytoplasm

• Protein domains

• Protein sequence (Human): P07195

• Homologous genes:  55647

• 2D PAGE: LDHB

• 3D Structure:  1I0Z 1T2F

• PTM: LDHB

• Pathways and interactions (According to Kegg, PIR)

• Pathway:

  Glycolysis / Gluconeogenesis
  Cysteine metabolism
  Pyruvate metabolism
  Propanoate metabolism

• Protein interactions: LDHB

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): CAB004641

• Clinical                            (According to OMIM, PubMed)

• OMIM : 150100
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy