MAPRE1

(Microtubule-associated protein, RP/EB family, member 1)

 

  • Alias                                 (According to NCBI)

 
  • EB1,
  • MGC117374,
  • MGC129946
  • adenomatous polyposis coli-binding protein EB1
  • May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
  • Location: 20q11.1-q11.23
  • Size: 30433 bp
  • exons: 6
  • DNA sequence (Human): NC_000020.9

  • CGH (20q11.1):  Losses (%) -0.6   Gain (%)  15.6  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_012325.1

  • Size: 2540 bp

  • cDNA libraries:

  • Size:268 amino acids: 29999 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasm. Note= Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome.

  • Protein domains

     

 

  • Pathway:

                        

  • Protein interactions: MAPRE1
  • Clinical                            (According to OMIM, PubMed)