• Alias                                 (According to NCBI)

• BM28,
• CCNL1,
• CDCL1,
• D3S3194,
• KIAA0030,
• MGC10606,
• MITOTIN, cdc19
• DNA replication licensing factor MCM2;
• MCM2 minichromosome maintenance deficient 2,
• mitotin; cell devision cycle-like 1;
• cyclin-like 1;
• minichromosome maintenance deficient (S. cerevisiae) 2 (mitotin);
• nuclear protein BM28

• Description   

  (According to SwissProt)

• Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 3q21
• Size:24027 bp
• exons: 15
• DNA sequence (Human): NC_000003

• CGH (3q21):  Losses (%) -1.7   Gain (%)  20.1  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD :
• SNPs: 4171

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  NM_004526.2

• Size: 3453 bp

• cDNA libraries: MCM2

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 904 amino acids; 101896 Da

• Subcellular location: Nucleus

• Protein domains

• Protein sequence (Human): P49736

• Homologous genes: 3325

• 2D PAGE: MCM2

• 3D Structure:  

• PTM: Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex. MCM2

• Pathways and interactions (According to BioCarta, KEGG, PIR)

• Pathway:

          KEgg DNA Replication

          KEgg Cell cycle

          Biocarta CDK Regulation of DNA replication

• Protein interactions: MCM2

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): CAB000303

• Clinical                            (According to OMIM, PubMed)

• OMIM : 116945
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy