CRTC1

(CREB regulated transcription coactivator 1)

 

  • Alias                                 (According to NCBI)

 

  
  • FLJ14027,
  • KIAA0616,
  • MECT1,
  • TORC1,
  • WAMTP1
  • mucoepidermoid carcinoma translocated 1;
  • transducer of regulated cAMP response element-binding protein (CREB) 1

 
  • Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses
  • Location: 19p13.11
  • Size: 98719 bp
  • exons: Transcript variant 1: 15
  •            Transcript variant 2: 14
  • DNA sequence (Human): NC_000019.8

  • CGH (19p13.11):  Losses (%) -2.2   Gain (%)  13.4    

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): Transcript variant 1 NM_001098482.1

  •                                          Transcript variant 2  NM_015321.2

  • Size: Transcript variant 1 7009 bp

  •          Transcript variant 2 6961 bp

  • cDNA libraries:

  • Size: 634 amino acids; 67300 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels.

  • Protein domains

     

  • Protein sequence (Human): Q6UUV9

  • Homologous genes:  41607

  • 2D PAGE:

  • 3D Structure:  

  • PTM: Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation, is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1. Phosphorylated upon DNA damage, probably by ATM or ATR. CRTC1

 

  • Pathway:

                        

  • Protein interactions: CRTC1
  • Clinical                            (According to OMIM, PubMed)