MET

(met proto-oncogene (hepatocyte growth factor receptor))

Alias (According to NCBI)	AUTS9, HGFR, RCCP2, c-Met HGF receptor; SF receptor; met proto-oncogene; met proto-oncogene tyrosine kinase; oncogene MET; scatter factor receptor
Description (According to SwissProt)	Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity.
Chromosomal location (According to NCBI, CGH: progenetix)	Location: 7q31 Size:125982 bp exons: 17 DNA sequence (Human): NC_000007.12 CGH (7q31): Losses (%) -3.9 Gain (%) 7.8
Mutations and SNPs (According to HGMD and SNP)	HGMD : MET SNPs: 4233
m-RNA (According to NCBI and CGAP)	mRNA sequence (Human): NM_000245.2 Size: 6641 bp cDNA libraries: MET
Protein (According to SwissProt, Swiss2D, PDB, dbPTM)	Size: 1390 amino acids:155527 Da Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Subcellular location: Membrane; Single-pass type I membrane protein. Protein domains Protein sequence (Human): P08581 Homologous genes: 206 2D PAGE: 3D Structure: 1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2G15 2UZX 2UZY PTM: MET
Pathways and interactions (According to Kegg, IntAct)	Pathway: `hsa04060 Cytokine-cytokine receptor interaction hsa04360 Axon guidance hsa04510 Focal adhesion hsa04520 Adherens junction hsa05120 Epithelial cell signaling in Helicobacter pylori infection hsa05210 Colorectal cancer hsa05211 Renal cell carcinoma hsa05218 Melanoma` Protein interactions: MET
Tissue (According to GeneNote, PubMed, HPA)	Tissue expression: PubMed Reference Human Protein Atlas (HPA): CAB005282
Clinical (According to OMIM, PubMed)	OMIM : 164860 PubMed: Early detection Diagnosis Prognosis Therapy