• Alias                                 (According to NCBI)

• DAMA-345G11.2,
• MGC111087,
• PERB11.1
• HLA class I antigen;
• MHC class I chain-related gene A protein;
• MHC class I chain-related protein A;
• OTTHUMP00000035033;
• OTTHUMP00000035034;
• Stress inducible class I homolog

• Description   

  (According to SwissProt)

• Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 6p21.3
• Size: 11818 bp
• exons: 6
• DNA sequence (Human): NT_113893.1

• CGH (6p21.3):  Losses (%) -1.1   Gain (%)  9.5    

• Mutations and SNPs (According to HGMD and SNP)

• HGMD : MICA
• SNPs: 4276

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  NM_000247.1

• Size: 1365 bp

• cDNA libraries: MICA

• Protein                        (According to SwissProt, Swiss2D, PDB)

• Size: 383 amino acids; 42915 Da
• Catalytic activity:

• Subcellular location: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum.

• Protein domains

     

• Protein sequence (Human): P30460

• Homologous genes:  

• 2D PAGE:

• 3D Structure:  1HYR 1B3J

• PTM:       N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation. Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation.

• Pathways and interactions (According to Kegg, IntAct)

• Pathway:

     Kegg   Natural killer cell mediated cytotoxicity

          BioCarta  Biosynthesis of neurotransmitters

          BioCarta  CARM1 and regulation of the Estrogen receptor

          BioCarta  Hemoglobin's Chaperone

          BioCarta  Pelp1 modulation of estrogen receptor activity

          BioCarta  Small leucine rich proteoglycan (SLRP) molecules

• Protein interactions: MICA

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): MICA

• Clinical                            (According to OMIM, PubMed)

• OMIM : 600169
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy