MMP1

(MATRIX METTALO PEPTIDASE 1)

 

  • Alias                                 (According to NCBI)

 
  • CLG
  • CLGN
  • fibroblast collagenase
  • interstitial collagenase
  • matrix metalloprotease 1
  • matrix metalloproteinase 1
  • Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. 
  • Location: 11q22.3
  • Size:  8244 bp
  • exons: 10
  • DNA sequence (Human): NC_000011.

  • CGH (11q22.3):  Losses (%) -14.5   Gain (%)  8.4  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_002421

  • Size:  1973 bp

  • cDNA libraries: MMP1
  • Size:   469 amino acids;   54007 Da
  • Catalytic activity: Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases).The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.s

  • Subcellular location: Secreted

  • Protein domains

     

  • Pathways and interactions (According to BioCarta, Kegg, DIP)

                                

  • Clinical                            (According to OMIM, PubMed)