• Alias                                 (According to NCBI)

• CLG4,
• CLG4A,
• MMP-II,
• MONA,
• TBE-1
• 72kD type IV collagenase;
• collagenase type IV-A;
• matrix metalloproteinase 2;
• matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase,
• 72kDa type IV collagenase);
• matrix metalloproteinase-II;
• neutrophil gelatinase

• Description   

  (According to SwissProt)

• In addition to gelatin and collagens, it cleaves KiSS1 at a Gly-|-Leu bond.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 16q13-q21
• Size: 27516 bp
• exons: 12
• DNA sequence (Human):NC_000016.8

• CGH (16q13):  Losses (%) -2.8   Gain (%)  5.6  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD : MMP2
• SNPs: 4313

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  NM_004530.2

• Size: 3546 bp

• cDNA libraries: MMP2

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 660 amino acids; 73882 Da
• Catalytic activity: Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.

• Protein domains

• Protein sequence (Human): P08253

• Homologous genes:  3329

• 2D PAGE: MMP2

• 3D Structure:   1GEN 1RTG 1EAK 1QIB 1CK7 1GXD 1KS0 1J7M
                         1HOV 1CXW

• PTM: MMP2

• Pathways and interactions (According to Kegg, PIR)

• Pathway:

  Leukocyte transendothelial migration
  GnRH signaling pathway
  Bladder cancer

• Protein interactions: MMP2

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA):  HPA001939

• Clinical                            (According to OMIM, PubMed)

• OMIM : 120360
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy