MMP9

(MATRIX METTALOPROTEIN 9)

 

  • Alias                                 (According to NCBI)

 
  • GELB;
  • CLG4B
  • gelatinase B
  • type V collagenase
  • macrophage gelatinase
  • 92kD type IV collagenase
  • matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase, 92kD type IV collagenase)
  • matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
  • May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond.
  • Location: 20q11.2-q13.1
  • Size: 7654 bp
  • exons: 13
  • DNA sequence (Human): NC_000020

  • CGH (20q11.2):  Losses (%) -0.6   Gain (%)  17.3  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_004994

  • Size: 2387 bp

  • cDNA libraries: MMP9
  • Size:707 amino acids;78427  Da
  • Catalytic activity: Cleavage of gelatin types I and V and collagen types IV and V.
  • Cofactor: Binds 2 zinc ions per subunit

                           Binds 3 calcium ions per subunit

  • Subcellular location: Extracellular matrix secreted

  • Protein domains

     

  • Protein sequence (Human): P14780

  • Homologous genes:  3659

  • 2D PAGE: mmp9

  • 3D Structure:  1ITV , 2ovx, 2OVZ, 2ow0, 1gkd, 2OW1, 1GKC, 1L6J, 2OW2

  • PTM:  MMP9 (Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9)  
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)