MSN

(moesin)

 

  • Alias                                 (According to NCBI)

 
  • RP1-261G23.1,
  • MGC70609,
  • VEGF,
  • VEGF-A,
  • VPF
  • vascular permeability factor
  • Probably involved in connections of major cytoskeletal structures to the plasma membrane.
  • Location: Xq11.2-q12
  • Size: 74283 bp
  • exons: 12
  • DNA sequence (Human): NC_000023.9

  • CGH (8q22): 

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_002444.2

  • Size: 3981 bp

  • cDNA libraries:

  • Size: 577 amino acids: 67820 Da
  • Catalytic activity:

  • Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm, cytoskeleton By similarity. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane By similarity.

  • Protein domains

     

  • Protein sequence (Human): P26038

  • Homologous genes:  1833

  • 2D PAGE:

  • 3D Structure:  1E5W 1EF1 1SGH

  • PTM: Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures
  • Pathways and interactions (According to Kegg, IntAct)

 

  • Pathway:

     hsa04670  Leukocyte transendothelial migration
     hsa04810  Regulation of actin cytoskeleton

                        

  • Protein interactions: MSN
  • Clinical                            (According to OMIM, PubMed)