NRAS

(neuroblastoma RAS viral (v-ras) oncogene homolog)

 

  • Alias                                 (According to NCBI)

 
  • ALPS4,
  • N-ras,
  • NRAS1
  • N-ras protein part 4;
  • v-ras neuroblastoma RAS viral oncogene homolog
  • Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
  • Location: 1p13.2
  • Size: 9931 bp
  • exons: 4
  • DNA sequence (Human): NC_000001.9

  • CGH (1p13.2):  Losses (%) 8.4   Gain (%)  2.2    

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_002524.3

  • Size: 4461 bp

  • cDNA libraries:

  • Size: 189 amino acids: 21229 Da
  • Catalytic activity:

  • Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus.

  • Protein domains

     

  • Protein sequence (Human): P01111

  • Homologous genes:  55661

  • 2D PAGE:

  • 3D Structure:  3CON

  • PTM: (Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.)
  • Pathways and interactions (According to Kegg, IntAct)

 

                        

  • Protein interactions: NRAS
  • Clinical                            (According to OMIM, PubMed)