• Alias                                 (According to NCBI)

• HMMH,
• HOGG1,
• MUTM,
• OGH1
• 8-hydroxyguanine DNA glycosylase;
• OGG1 type 1d;
• OGG1 type 1e;
• OGG1 type 1g;
• OGG1 type 1h

• Description   

  (According to SwissProt)

• DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 3p26.2
• Size: 17638 bp
• DNA sequence (Human):NC_000003.10

• CGH (3p26.2):  Losses (%) -29.6   Gain (%)  1.1  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD : OGG1
• SNPs: 4968

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  

          Transcript varient 1a: NM_002542.4   

          Transcript varient 1b: NM_016819.2

          Transcript varient 1c: NM_016820.2

          Transcript varient 2a: NM_016821.1

          Transcript varient 2b: NM_016826.1

          Transcript varient 2c: NM_016827.1

          Transcript varient 2d: NM_016828.1            

          Transcript varient 2e: NM_016829.1

• cDNA libraries: HOGG1

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 345 amino acids; 38782 Da
• Catalytic activity: he C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

• Subcellular location:

           Isoform 1A: Nucleus.

           Isoform 2A: Mitochondrion.

• Protein domains

     

• Protein sequence (Human): O15527

• Homologous genes:  1909

• 2D PAGE: HOGG1

• 3D Structure:  1M3Q 2NOH 1LWY 1M3H 2NOB 1LWW 1EBM 1KO9
                         2NOE 1N39 1N3A 1LWV 2NOF 2NOI 1HU0 2NOZ
                         1YQR 1YQM 1YQK 2NOL 2I5W 1YQL 1FN7 1N3C
       

• PTM: HOGG1

• Pathways and interactions (According to Kegg, PIR)

• Pathway:

          Base excision repair

• Protein interactions: HOGG1

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA):  HPA027514

• Clinical                            (According to OMIM, PubMed)

• OMIM : 601982
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy