• Alias                                 (According to NCBI)

• FLJ16691

• hCG_1778014

• Description   

  (According to SwissProt)

• Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 12q24.31
• Size: 55253 bp
• Exons: 6
• DNA sequence (Human):  NC_001012

• CGH (12q24.31):  Losses (%) -2.2   Gain (%)  4.5    

• Mutations and SNPs (According to HGMD and SNP)

• HGMD : PAX
• SNPs: 5829

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human): NM_002859

• Size: 3595 bp

• cDNA libraries: pax

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size:591 amino acids; 64533 Da
• Catalytic activity:

• Subcellular location: Cytoplasm, cytoskeleton. Cell junction, focal adhesion.

• Protein domains

• Protein sequence (Human): P49023

• Homologous genes: 37697

• 2D PAGE: pax

• 3D Structure: 1ow6

• PTM:  PAX (Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.)

• Pathways and interactions (According to BioCarta,Kegg. DIP)

         Pathway: 

• apoptotic signaling in response to DNA damage

• cell to cell adhesion signaling

• CXCR4 signaling pathway

• integrin signalling pathway

• signalling of hepatocyte growth factor receptor

• VEGF, hypoxia and angiogenesis

• Erk and PI-3  Kinase are necessary forcollagen binding in corneal epithelia

• m-calpain and friends in cell motility

• u-calpain and friends in cell motility

• leukocyte transendothelial migration

• regulation of actin cytoskeleton

         Protein interactions: 'EBI-702209,EBI-348482'

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): CAB003841

• Clinical                            (According to OMIM, PubMed)

• OMIM : 602505
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy