PDGFB

(platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog))

 

  • Alias                                 (According to NCBI)

 

  
  • FLJ12858,
  • PDGF2,
  • SIS,
  • SSV,
  • c-sis
  • HUMANES PDGF-B GEN AUS PGEM2-PDGF-B,
  • FLANKIERT VON 5'-ECORI UND 3'-HINDIII RESTRIKTIONSSCHNITTSTELLEN;
  • PDGF, B chain;
  • PDGF-B VORLAEUFERSEQUENZ;
  • Platelet-derived growth factor, beta polypeptide (oncogene SIS);
  • becaplermin; oncogene SIS;
  • platelet-derived growth factor 2;
  • platelet-derived growth factor beta;
  • platelet-derived growth factor, B chain;
  • v-sis platelet-derived growth factor beta polypeptide (simian sarcoma viral oncogene homolog)
  • Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.
  • Location: 22q13.1
  • Size: 21272 bp
  • exons: 6
  • DNA sequence (Human): NC_000022.9

  • CGH (22q13.1):  Losses (%) -1.1   Gain (%)  15.1  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  Transcript variant1: NM_002608.1 

  •                                           Transcript variant2: NM_033016.1

  • Size: Transcript variant1: 3373 bp

  •          Transcript variant2 2378 bp

  • cDNA libraries:

  • Size: 241 amino acids: 27283 Da
  • Catalytic activity:

  • Subcellular location: Secreted.

  • Protein domains

     

 

                        

  • Protein interactions: PDGFB
  • Clinical                            (According to OMIM, PubMed)