PGAM1

(Phosphoglycerate Mutase 1)

 

  • Alias                                 (According to NCBI)

 

  
  • RP11-452K12.8,
  • PGAMA
  • OTTHUMP00000059414;
  • phosphoglycerate mutase A, nonmuscle form

 
  • Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
  • Location: 10q25.3
  • Size: 7172 bp
  • exons: 4
  • DNA sequence (Human): NC_000010.9

  • CGH (10q25.3):  Losses (%) -10.1   Gain (%)  1.7  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Protein                        (According to UniProt, Swiss2D, PDB, dbPTM)
  • Size: 254 amino acids; 28804 Da
  • Catalytic activity:

    2-phospho-D-glycerate = 3-phospho-D-glycerate.

    3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.

    2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate.

  • Subcellular location:

  • Protein domains

     

  • Pathways and interactions (According to Kegg, PIR)

 

                        

  • Protein interactions: PGAM1
  • Clinical                            (According to OMIM, PubMed)