• Alias                                 (According to NCBI)

• MGC142161,
• MGC142163,
• PI3K,
• p110-alpha
• PI3-kinase p110 subunit alpha;
• PtdIns-3-kinase p110;
• phosphatidylinositol 3-kinase, catalytic,
• 110-KD, alpha;
• phosphatidylinositol 3-kinase,
• catalytic,
• alpha polypeptide;
• phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform

• Description   

  (According to SwissProt)

• Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 3q26.32
• Size: 86190 bp
• exons: 13
• DNA sequence (Human): NC_000003.10

• CGH (3q26):  Losses (%) -1.7   Gain (%)  34.6  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD :
• SNPs: 5290

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  NM_006218.2

• Size: 3724 bp

• cDNA libraries: PIK3CA

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 1068 amino acids; 124284 Da
• Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.

• Protein domains

• Protein sequence (Human): P42336

• Homologous genes:  21249

• 2D PAGE: PIK3CA

• 3D Structure:  2RD0 2ENQ

• PTM: PIK3CA

• Pathways and interactions (According to Kegg,IntAct)

• Pathway:

  hsa00562  Inositol phosphate metabolism
 hsa04012  ErbB signaling pathway
 hsa04070  Phosphatidylinositol signaling system
 hsa04150  mTOR signaling pathway
 hsa04210  Apoptosis
 hsa04370  VEGF signaling pathway
 hsa04510  Focal adhesion
 hsa04620  Toll-like receptor signaling pathway
 hsa04630  Jak-STAT signaling pathway
 hsa04650  Natural killer cell mediated cytotoxicity

 hsa04660  T cell receptor signaling pathway
 hsa04662  B cell receptor signaling pathway
 hsa04664  Fc epsilon RI signaling pathway
 hsa04670  Leukocyte transendothelial migration
 hsa04810  Regulation of actin cytoskeleton
 hsa04910  Insulin signaling pathway
 hsa04930  Type II diabetes mellitus
 hsa05210  Colorectal cancer
 hsa05211  Renal cell carcinoma
 hsa05212  Pancreatic cancer
 hsa05213  Endometrial cancer
 hsa05214  Glioma
 hsa05215  Prostate cancer
 hsa05218  Melanoma
 hsa05220  Chronic myeloid leukemia
 hsa05221  Acute myeloid leukemia
 hsa05222  Small cell lung cancer
 hsa05223  Non-small cell lung cancer

• Protein interactions: PIK3CA

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): HPA009985 

• Clinical                            (According to OMIM, PubMed)

• OMIM : 171834
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy