• Alias                                 (According to NCBI)

• DOD,
• UBL5
• peptidyl-prolyl cis/trans isomerase,
• NIMA-interacting; prolyl isomerase;
• protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1;
• protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1

• Description   

  (According to SwissProt)

• Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzing pSer/Thr-Pro cis/trans isomerizations.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 19p13
• Size: 14360 bp
• exons: 4
• DNA sequence (Human):NC_000019.8

• CGH (19p13):  Losses (%) -2.2   Gain (%)  14.0  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD :
• SNPs: 5300

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  NM_006221.2

• Size: 997 bp

• cDNA libraries: PIN1

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 163 amino acids; 18243 Da
• Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).

• Subcellular location: Nucleus

• Protein domains

• Protein sequence (Human): Q13526

• Homologous genes:  4531

• 2D PAGE: PIN1

• 3D Structure:  1PIN 2ITK 2Q5A 2F21 1F8A 1ZCN 1NMW 1NMV

• PTM: PIN1

• Pathways and interactions (According to BioCarta, IntAct)

• Pathway:

          How progesterone initiates oocyte membrane

• Protein interactions: PIN1

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): CAB004528

• Clinical                            (According to OMIM, PubMed)

• OMIM : 601052
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy