PKM2

(Pyruvate Kinase, muscle)

 

  • Alias                                 (According to NCBI)

 
  • CTHBP,
  • MGC3932,
  • OIP3,
  • PK3,
  • PKM,
  • TCB,
  • THBP1
  • OPA-interacting protein 3;
  • PK, muscle type;
  • pyruvate kinase M2;
  • thyroid hormone-binding protein, cytosolic
  • Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP.
  • Location: 15q22
  • Size:32315 bp
  • exons: 10
  • DNA sequence (Human): NC_000015.8

  • CGH (15q22):  Losses (%) -1.7   Gain (%)  8.4  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): Transcript variant1:  NM_002654.3

  •                                          Transcript variant2:  NM_182470.1

  •                                          Transcript variant3:  NM_182471.1

  • Size: Transcript variant1: 2479 bp

  •          Transcript variant2: 2674 bp

  •          Transcript variant3: 2498 bp

  • cDNA libraries:

  • Size: 531 amino acids: 57937 Da
  • Catalytic activity: ATP + pyruvate = ADP + phosphoenolpyruvate.

  • Subcellular location:

  • Protein domains

     

  • Protein sequence (Human):P14618

  • Homologous genes:  37650

  • 2D PAGE:

  • 3D Structure:  1T5A, 1ZJH

  • PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.

 

  • Pathway: PATH: hsa00010  Glycolysis / Gluconeogenesis
    PATH: hsa00230  Purine metabolism
    PATH: hsa00620  Pyruvate metabolism
    PATH: hsa00710  Carbon fixation
    PATH: hsa04910  Insulin signaling pathway
    PATH: hsa04930  Type II diabetes mellitus

                        

  • Protein interactions: PKM2
  • Clinical                            (According to OMIM, PubMed)