PLK1

(polo-like kinase 1 (Drosophila))

 

  • Alias                                 (According to NCBI)

 

  • polo-like kinase 1 (Drosophila)

  • cell cycle regulated protein kinase;

  • polo (Drosophia)-like kinase;

  • polo like kinase;

  • polo-like kinase
  • Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis.
  • Location: 16p12.1
  • Size: 11488 bp
  • exons: 10
  • DNA sequence (Human): NC_000016.8

  • CGH (16p12.1):  Losses (%) -1.1  Gain (%)  5.0    

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_005030.3

  • Size: 2204 bp

  • cDNA libraries:

  • Size: 603 amino acids: 68255 Da
  • Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

  • Subcellular location: Nucleus.

  • Protein domains

     

  • Protein sequence (Human): P53350

  • Homologous genes:  3690

  • 2D PAGE:

  • 3D Structure:  1Q4K 1Q4O 1UMW 2OGQ 2OJS 2OU7 2OWB 2RKU 3BZI

  • PTM: PLK (Catalytic activity is enhanced by phosphorylation of Thr-210 and/or Ser-137.Autophosphorylation and phosphorylation of Ser-137 are not significant events during activation of PLK1 in M phase. )

 

                        

  • Protein interactions: PLK
  • Clinical                            (According to OMIM, PubMed)