PLS1

(Plastin 1)

 

  • Alias                                 (According to NCBI)

 
  • Plastin 1
  • PLS1

  • Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene

  • Actin-bundling protein in the absence of calcium.
  • Location: 3q23
  • Size: 117278 bp
  • exons:
  • DNA sequence (Human):  NC_000003.11

  • CGH (3q23):  Losses (%) -1.1   Gain (%) 2.3  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 629 amino acids; 70253 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasm.

  • Protein domains

     

  • Protein sequence (Human): Q14651

  • Homologous genes:

  • 2D PAGE:

  • 3D Structure:

  • PTM: PLS1
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions: Q14651
  • Clinical                            (According to OMIM, PubMed)