PPP1CA

(protein phosphatase 1, catalytic subunit, alpha isoform)

 

  • Alias                                 (According to NCBI)

 
  • MGC15877,
  • MGC1674,
  • PP-1A,
  • PPP1A
  • protein phosphatase 1,
  • catalytic subunit, alpha;
  • serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit

 
  • Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.
  • Location: 11q13
  • Size:3725 bp
  • exons:

          Transcript variant 1:  7

          Transcript variant 2:  6

          Transcript variant 3:  7

  • CGH (11q13):  Losses (%) -3.4   Gain (%)  34.1  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  

         

          Transcript variant 1:  NM_002708.3

          Transcript variant 2:  NM_206873.1

          Transcript variant 3:  NM_001008709.1

  • Size:

          Transcript variant 1:  1488

          Transcript variant 2:  1356

          Transcript variant 3:  1521
  • Protein                        (According to SwissProt, PDB, dbPTM)
  • Size: 330 amino acids; 37512 Da
  • Catalytic activity: A phosphoprotein + H2O = a protein + phosphate.

  • Subcellular location: Cytoplasm

  • Protein domains

     

  • Pathways and interactions (According to Kegg, IntAct)

 

  • Pathway:

   Focal adhesion
   Long-term potentiation
   Regulation of actin cytoskeleton
   Insulin signaling pathway

 

                        

  • Protein interactions: PPP1CA
  • Clinical                            (According to OMIM, PubMed)