PRDX1

(Peroxiredoxin 1)

 

  • Alias                                 (According to NCBI)

 
  • MSP23,
  • NKEFA,
  • PAG,
  • PAGA,
  • PAGB,
  • PRX1,
  • PRXI,
  • TDPX2
  • natural killer-enhancing factor A;
  • proliferation-associated gene A;
  • thioredoxin-dependent peroxide reductase 2
  • Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
  • Location: 1p34.1
  • Size: 10903 bp
  • exons: 5
  • DNA sequence (Human): NC_000001.9

  • CGH (1p34.1):  Losses (%) -2.8   Gain (%)  2.8 

  • Mutations and SNPs (According to HGMD and SNP)

 
  • HGMD :
  • SNPs:

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):

  • Transcript variant1:   NM_002574.2

  • Transcript variant2: NM_181696.1

  • Transcript variant3: NM_181697.1

  • Size:

  • Transcript variant1: 1262 bp

  • Transcript variant2: 1236 bp

  • Transcript variant3: 1042 bp

  • cDNA libraries:

  • Size:199  amino acids: 22110 Da
  • Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH

  • Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

  • Protein domains

     

  • Protein sequence (Human): Q06830

  • Homologous genes:  99789

  • 2D PAGE: PRDX1

  • 3D Structure:  2RII

  • PTM: Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.

 

  • Pathway:

                        

  • Protein interactions: PRDX1
  • Clinical                            (According to OMIM, PubMed)