PRDX2

(Peroxiredoxin 2)

 

  • Alias                                 (According to NCBI)

 
  • MGC4104,
  • NKEFB,
  • PRP,
  • PRX2,
  • PRXII,
  • TDPX1,
  • TSA
  • natural killer-enhancing factor B;
  • thiol-specific antioxidant 1;
  • thioredoxin peroxidase 1;
  • thioredoxin-dependent peroxide reductase 1;
  • torin
  • Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
  • Location: 19p13.2
  • Size: 5061 bp
  • exons:
  • Transcript variant1: 5
  • Transcript variant3: 2
  • DNA sequence (Human): NC_000019.8

  • CGH (19p13.2):  Losses (%) -2.8   Gain (%)  13.4 

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):

  • Transcript variant1:  NM_005809.4

  • Transcript variant3:  NM_181738.1

  • Size:

  • Transcript variant1: 1039 bp

  • Transcript variant3:  710 bp

  • cDNA libraries:

  • Size: 198 amino acids: 21892 Da
  • Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.

  • Subcellular location: Cytoplasm

  • Protein domains

     

 

  • Pathway:

                        

  • Protein interactions: PRDX2
  • Clinical                            (According to OMIM, PubMed)