PRDX3

(Peroxiredoxin 3)

 

  • Alias                                 (According to NCBI)

 
  • AOP-1, AOP1, MER5, MGC104387, MGC24293, PRO1748, SP-22
  • antioxidant protein 1; thioredoxin-dependent peroxide reductase
  • Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
  • Location: 10q25-q26
  • Size: 11139 bp
  • exons: 7
  • DNA sequence (Human): NC_000010.9

  • CGH (10q25):  Losses (%) -14.5   Gain (%)  2.2  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):

  • Transcript variant1:  NM_006793.2

  • Transcript vairant2:NM_014098.2

  • Size:

  • Transcript variant1: 1591 bp

  • Transcript vairant2: 1537 bp

  • cDNA libraries:

  • Size: 256 amino acids: 27693 Da
  • Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.

  • Subcellular location: Mitochondrion

  • Protein domains

     

 

  • Pathway:

                        

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)