PSME1

(proteasome (prosome, macropain) activator subunit 1)

 

  • Alias                                 (According to NCBI)

 
  • proteasome (prosome, macropain) activator subunit 1
  • PA28A
  • IFI5111
  • REGalpha
  • PA28alpha
  • PSME1

 
  • Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
  • Location:14q11.2
  • Size: 2799 bp
  • exons:
  • DNA sequence (Human):  NC_0000014.8

  • CGH (14q11.2):  Losses (%) -3.4   Gain (%) 7.8  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 249 amino acids; 28723 Da
  • Catalytic activity:

  • Subcellular location:

  • Protein domains

     

  • Protein sequence (Human): Q06323

  • Homologous genes:

  • 2D PAGE:

  • 3D Structure:1AVO

  • PTM:

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions: Q06323
  • Clinical                            (According to OMIM, PubMed)