• Alias                                 (According to NCBI)

• HHM,
• MGC14611,
• PLP,
• PTHR,
• PTHRP
• PTH-related protein;
• humoral hypercalcemia of malignancy;
• osteostatin;
• parathyroid hormone-like protein;
• parathyroid hormone-like related protein;
• parathyroid hormone-related protein;
• parathyroid-like protein

• Description   

  (According to SwissProt)

• Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth.
• Osteostatin is a potent inhibitor of osteoclastic bone resorption.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 12p12.1-p11.2
• Size: 16900 bp
• exons:

          Transcript variant 1: 3

          Transcript variant 2  2

          Transcript variant 3: 2

          Transcript variant 4: 3

• DNA sequence (Human): NC_000012.10

• CGH (12p12.1):  Losses (%) -5.0   Gain (%)  7.8  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD :
• SNPs: 5744

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):

          Transcript variant 1:  NM_198965.1

          Transcript variant 2:  NM_002820.2

          Transcript variant 3   NM_198964.1

          Transcript variant 4: NM_198966.1

• Size:

          Transcript varient 1:  1331

          Transcript varient 2   1881

          Transcript varient 3   1862

          Transcript varient 4:  1312

• cDNA libraries: PTHLH

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 177 amino acids; 20194 Da
• Catalytic activity:

• Subcellular location: Cytoplasm. Nucleus. Secreted

• Protein domains

• Protein sequence (Human): P12272

• Homologous genes:  2113

• 2D PAGE: PTHLH

• 3D Structure:  1BZG

• PTM:  PTHLH  (There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.)

• Pathways and interactions (According to  PIR)

• Pathway:

• Protein interactions: PTHLH

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): CAB000072

• Clinical                            (According to OMIM, PubMed)

• OMIM : 168470
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy