• Alias                                 (According to NCBI)

• HAP,
• NR1B2,
• RRB2
• HBV-activated protein;
• RAR-epsilon;
• hepatitis B virus activated protein;
• retinoic acid receptor beta 2;
• retinoic acid receptor beta 4;
• retinoic acid receptor beta 5;
• retinoic acid receptor,
• beta polypeptide

• Description   

  (According to SwissProt)

• This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 3p24
• Size: 169667 bp
• exons: 

          Isoform A :- 7

          Isoform B :- 5

• DNA sequence (Human): NC_000003.10

• CGH (3p24):  Losses (%) -29.6   Gain (%)  0.6  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD :
• SNPs: 5915

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  

          Trancript varient 1 : NM_000965.2&

          Transcript varient 2: NM_016152.2

• Size:

          Trancript varient 1 : 3119

          Transcript varient 2: 2762

• cDNA libraries: RARB

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 455 amino acids ; 50489 Da
• Catalytic activity:

• Subcellular location:

  Isoform Beta-1: Nucleus.

  Isoform Beta-2: Nucleus.

  Isoform Beta-4: Cytoplasm

• Protein domains

• Protein sequence (Human): P10826

• Homologous genes:  68100

• 2D PAGE: RARB

• 3D Structure:  1XAP 1HRA

• PTM: RARB

• Pathways and interactions (According to kegg, IntAct)

• Pathway:

          Small cell lung cancer

          Non-small cell lung cancer

• Protein interactions: RARB

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA):  HPA004174 

• Clinical                            (According to OMIM, PubMed)

• OMIM : 180220
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy