REL

(v-rel reticuloendotheliosis viral oncogene homolog (avian))

 

  • Alias                                 (According to NCBI)

 
  • C-Rel
  • C-Rel proto-oncogene protein;
  • oncogene REL, avian reticuloendotheliosis;
  • v-rel avian reticuloendotheliosis viral oncogene homolog;
  •  v-rel reticuloendotheliosis viral oncogene homolog
  • Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
  • Location: 2p13-p12
  • Size: 41427 bp
  • exons:
  • DNA sequence (Human): NC_000002.10

  • CGH (2p13):  Losses (%) -2.2   Gain (%)  5.0  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_002908.2

  • Size: 2592 bp

  • cDNA libraries:

  • Size: 619 amino acids: 68520 Da
  • Catalytic activity:

  • Subcellular location: Nucleus

  • Protein domains

     

  • Protein sequence (Human): Q04864

  • Homologous genes:  2182

  • 2D PAGE:

  • 3D Structure:  

  • PTM: REL

 

  • Pathway:

                        

  • Protein interactions: REL
  • Clinical                            (According to OMIM, PubMed)