RIN1

(RAS and RAB interactor 1)

 

  • Alias                                 (According to NCBI)

 
  • ras inhibitor 1;
  • ras inhibitor RIN1
  • Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
  • Location: 11q13.1
  • Size:4459 bp
  • exons: 10
  • DNA sequence (Human): NC_000011.8

  • CGH (11q13.1):  Losses (%) -3.4   Gain (%)  13.4  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 783 amino acids; 84099 Da
  • Subunit: Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351.

  • Subcellular location: Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.

  • Protein domains

     

 

  • Pathway:

          Caspase cascade in apoptosis

          CTL mediated immune response against target cells

          D4-GDI signaling pathway

          Downregulation of MTA-3 in ER-negative breat tumors

          Erythropoeitin mediated neuroprotection through NF-Kb

          Granzyme  mediated Apoptosis pathway

          Nitric oxide signaling pathway

          SOMOylation a s a mechanism to modulate ctBP-dependent gene responses

          Synaptic proteins at the synaptic junction

          TGF beta signaling pathway                  

  • Protein interactions: RIN1
  • Clinical                            (According to OMIM, PubMed)