SERPINB5

(Serpin peptidase inhibitor, clade B {ovalalbubin}, member 5)

 

  • Alias                                 (According to NCBI)

 
  • PI5, maspin
  • protease inhibitor 5 (maspin);
  • serine (or cysteine) proteinase inhibitor,
  • clade B (ovalbumin), member 5
  • Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
  • Location: 18q21.3
  • Size: 28099 bp
  • exons: 6
  • DNA sequence (Human): NC_000018.8

  • CGH (18q21.3):  Losses (%) -25.7   Gain (%)  1.7  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Protein                        (According to SwissProt, PDB, dbPTM)
  • Size: 375 amino acids; 42138 Da
  • Catalytic activity:

  • Subcellular location: Secreted, extracellular space.

  • Protein domains

     

  • Pathways and interactions (According to Kegg)

 

                        

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)