SERPINE1

(serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1)

 

  • Alias                                 (According to NCBI)

 

  
  • PAI,
  • PAI-1,
  • PAI1,
  • PLANH1
  • plasminogen activator inhibitor, type I;
  • plasminogen activator inhibitor-1;
  • serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

 
  • This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.
  • Location: 7q21.3-q22
  • Size: 11855 bp
  • exons: 8
  • DNA sequence (Human): NC_000007.12

  • CGH (7q21.3):  Losses (%) -2.8   Gain (%)  11.2    

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_000602.1

  • Size: 2876 bp

  • cDNA libraries:

  • Protein                        (According to SwissProt, Swiss2D, PDB,)
  • Size: 402 amino acids: 45060 Da
  • Catalytic activity:

  • Subcellular location: Secreted.

  • Protein domains

     

  • Protein sequence (Human): P05121

  • Homologous genes:  68070

  • 2D PAGE: PAI1

  • 3D Structure:  1LJ5 1A7C 1DVN 1OC0 1DVM 1C5G 1DB2 9PAI
         1B3K

  • PTM: Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.

 

                        

  • Protein interactions: PAI1
  • Clinical                            (According to OMIM, PubMed)