SNX4

(Sorting nexin)

 

  • Alias                                 (According to NCBI)

 
  • Sorting nexin
  • ATG24B
  • SNX4

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.
  • Location: 3q21.2
  • Size: 73565 bp
  • exons:
  • DNA sequence (Human):  NC_000003.11

  • CGH (3q21.2):  Losses (%) -1.7   Gain (%) 20.7  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_003794

  • Size:  2567 bp

  • cDNA libraries:
  • Size: 450 amino acids; 51909 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasm.

  • Protein domains

     

  • Protein sequence (Human): O95219

  • Homologous genes:

  • 2D PAGE:

  • 3D Structure:

  • PTM: SNX4
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions: O95219
  • Clinical                            (According to OMIM, PubMed)