SPARC

(secreted protein, acidic, cysteine-rich (osteonectin))

 

  • Alias                                 (According to NCBI)

 
  • ON
  • cysteine-rich protein;
  • osteonectin;
  • secreted protein, acidic, cysteine-rich
  • Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
  • Location: 5q31.3-q32
  • Size: 25510 bp
  • exons: 9
  • DNA sequence (Human): NC_000005.8

  • CGH (5q31.3):  Losses (%) -10.6   Gain (%)  3.4  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_003118.2

  • Size: 3178 bp

  • cDNA libraries:

  • Size: 303 amino acids: 34632 Da
  • Catalytic activity:

  • Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane.

  • Protein domains

     

 

  • Pathway:

                        

  • Protein interactions: SPARC
  • Clinical                            (According to OMIM, PubMed)