SPHK1

(sphingosine kinase 1)

 

  • Alias                                 (According to NCBI)

 
  • SPHK

 
  • Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
  • Location: 17q25.2
  • Size: 3240 bp
  • exons: Transcript variant 1: 5
  •            Transcript variant 2 : 6
  • DNA sequence (Human): NC_000017.9

  • CGH (17q25.2):  Losses (%) -1.7   Gain (%)  11.2  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  Transcript variant 1: NM_021972.2 

  •                                           Transcript variant 2: NM_182965.1

  • Size:  Transcript variant 1: 1869

  •           Transcript variant 2: 2174 bp

  • cDNA libraries:

  • Size: 384 amino acids; 42518 Da
  • Catalytic activity:

    ATP + sphinganine = ADP + sphinganine 1-phosphate.

    ATP + sphingosine = ADP + sphingosine 1-phosphate.

  • Protein domains

     

  • Protein sequence (Human): Q9NYA1

  • Homologous genes:  39748

  • 2D PAGE:

  • 3D Structure:  

  • PTM:  SPHK1
  • Pathways and interactions (According to Kegg, IntAct)

 

                        

  • Protein interactions: SPHK1
  • Clinical                            (According to OMIM, PubMed)