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- Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a
lipid mediator with both intra- and extracellular functions. Also acts on
D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as
D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or
phosphatidylinositol.
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- Location: 17q25.2
- Size: 3240 bp
- exons: Transcript variant 1: 5
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Transcript variant 2 : 6
- DNA sequence (Human): NC_000017.9
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- Mutations and SNPs (According
to HGMD and SNP)
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mRNA
sequence (Human): Transcript variant 1: NM_021972.2
Transcript variant 2: NM_182965.1
Size:
Transcript variant 1: 1869
Transcript
variant 2: 2174 bp
cDNA
libraries:
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- Pathways and interactions
(According to Kegg, IntAct)
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