TAGLN

(Transgelin)

 

  • Alias                                 (According to NCBI)

 
  • Transgelin
  • SM22
  • SMCC
  • TAGLN1
  • WS3-10
  • The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation.
  • Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
  • Location: 11q23.2
  • Size: 11518 bp
  • exons:
  • DNA sequence (Human):  NC_0000011.9

  • CGH (11q23.2):  Losses (%) -17.9   Gain (%) 5.6    

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 201 amino acids; 22611 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasm

  • Protein domains

     

  • Protein sequence (Human): Q01995

  • Homologous genes:

  • 2D PAGE:

  • 3D Structure:

  • PTM: TAGLN
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions: Q01995
  • Clinical                            (According to OMIM, PubMed)