TIAM1

(T-cell lymphoma invasion and metastasis 1)

 

  • Alias                                 (According to NCBI)

 
  • FLJ36302
  • human T-lymphoma invasion and metastasis inducing TIAM1 protein
  • Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
  • Location: 21q22.11
  • Size: 440555 bp
  • exons: 19
  • DNA sequence (Human): NC_000021.7

  • CGH (21q22.11):  Losses (%) -15.6   Gain (%)  2.2  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_003253.2  

  • Size: 7218 bp

  • cDNA libraries:

  • Size: 1591 amino acids: 177508 Da
  • Catalytic activity:
  • Subcellular location:

  • Protein domains

     

  • Pathways and interactions (According to Kegg, IntAct)

 

                        

  • Protein interactions: TIAM1
  • Clinical                            (According to OMIM, PubMed)