TK1

(Thymidine kinase 1)

 

  • Alias                                 (According to NCBI)

 
  • TK2
  • Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells
  • Location: 17q23.2-q25.3
  • Size: 13126 bp
  • exons: 7
  • DNA sequence (Human): NC_000017

  • CGH (17q23.2):  Losses (%) -1.7   Gain (%)  10.1  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_003258

  • Size: bp

  • cDNA libraries: TK1
  • Size:234amino acids; 25469 Da
  • Catalytic activity: ATP + thymidine = ADP + thymidine 5'-phosphate.

  • Subcellular location: Cytoplasm

  • Protein domains

     

  • Pathways and interactions (According to BioCarta, DIP)

 

                        

  • Protein interactions: TK1
  • Clinical                            (According to OMIM, PubMed)