TYMP

(Thymidine phosphorylase)

 

  • Alias                                 (According to NCBI)

 
  • ECGF1,
  • MNGIE,
  • PDECGF,
  • TP, hPD-ECGF
  • endothelial cell growth factor 1 (platelet-derived);
  • gliostatin
  • May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.

    Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

     
  • Location: 22q13.33
  • Size:4275 bp
  • exons:
  • DNA sequence (Human): NC_000022.9

  • CGH (22q13.33):  Losses (%) -1.1   Gain (%)  14.5

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_001953.3

  • Size: 1659 bp

  • cDNA libraries:

  • Size: 482 amino acids: 49955 Da
  • Catalytic activity: Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

  • Subcellular location:

  • Protein domains

     

  • Pathways and interactions (According to Kegg, PIR)

 

                        

  • Protein interactions: TYMP
  • Clinical                            (According to OMIM, PubMed)