UBE2C

(ubiquitin-conjugating enzyme E2C)

 

  • Alias                                 (According to NCBI)

 

  
  • RP3-447F3.1,
  • UBCH10,
  • dJ447F3.2
  • cyclin-selective ubiquitin carrier protein;
  • mitotic-specific ubiquitin-conjugating enzyme;
  • ubiquitin carrier protein E2-C;
  • ubiquitin-protein ligase C
  • Catalyzes the covalent attachment of ubiquitin to other proteins. Required for the destruction of mitotic cyclins.
  • Location: 20q13.12
  • Size: 4342 bp
  • exons:
  • Transcript variant 1: 6
  • Transcript variant 2: 6
  • Transcript variant 3: 5
  • Transcript variant 4: 5
  • Transcript variant 5: 5
  • Transcript variant 6: 3
  • DNA sequence (Human): NC_000020.9

  • CGH (20q13.12):  Losses (%) -1.7   Gain (%)  18.4  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):

  • Transcript variant 1: NM_007019.2

  • Transcript variant 2: NM_181799.1

  • Transcript variant 3: NM_181800.1

  • Transcript variant 4: NM_181801.1

  • Transcript variant 5: NM_181802.1

  • Transcript variant 6: NM_181803.1

  • Size:

  • Transcript variant 1: 823 bp

  • Transcript variant 2: 766 bp

  • Transcript variant 3: 744 bp

  • Transcript variant 4: 936 bp

  • Transcript variant 5: 1490 bp

  • Transcript variant 6: 520 bp

  • cDNA libraries:

  • Size: 179 amino acids: 19652 Da
  • Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

  • Protein domains

     

  • Pathways and interactions (According to Kegg, IntAct)

 

                        

  • Protein interactions: UBE2C
  • Clinical                            (According to OMIM, PubMed)