UCHL1

(ubiquitin thiolesterase)

 

  • Alias                                 (According to NCBI)

 
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
  • PARK5
  • PGP95
  • PGP9.5
  • Uch-L1
  • PGP 9.5
  • UCHL1
  • Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
  • Location: 4p14
  • Size: 11518 bp
  • exons:
  • DNA sequence (Human):  NC_000004.11

 

 

  • CGH (4p14):  Losses (%) -15.6   Gain (%) 1.1  

 
  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_004181.4

  • Size: 1141 bp

  • cDNA libraries:
  • Size: 223 amino acids; 24824 Da
  • Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

  • Subcellular location: Cytoplasm

  • Protein domains

     

  • Protein sequence (Human): P09936

  • Homologous genes:

  • 2D PAGE:

  • 3D Structure: 2ETL

  • PTM:

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions: Q06323
  • Clinical                            (According to OMIM, PubMed)