• Alias                                 (According to NCBI)

• RP11-544M22.5,
• FCHL,
• FCHL1,
• HYPLIP1,
• MLTF,
• MLTFI,
• UEF
• major late transcription factor 1;
• upstream stimulatory factor 1

• Description   

  (According to SwissProt)

• Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 1q22-q23
• Size: 6717 bp
• exons:

          Transcript variant 1 : 10

          Transcript variant 2:  7

• DNA sequence (Human): NC_000001.9

• CGH (1q22):  Losses (%) -17.9   Gain (%)  8.9  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD : USF1
• SNPs: 7391

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  

          Transcript variant 1 : NM_007122.3

          Transcript variant 2:  NM_207005.1

• Size:

          Transcript variant 1 : 1831

          Transcript variant 2:  1800

• cDNA libraries: USF1

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 310 amino acids; 33538 Da
• Catalytic Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an homodimer or a heterodimer (USF1/USF2). Interacts with varicella-zoster virus IE62 protein.

• Subcellular location: Nucleus

• Protein domains

     

• Protein sequence (Human): P22415

• Homologous genes:  31426

• 2D PAGE: USF1

• 3D Structure:  1AN4

• PTM: USF1

 

• Pathways and interactions (According to PIR)

• Pathway:

• Protein interactions: USF1

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): CAB001480

• Clinical                            (According to OMIM, PubMed)

• OMIM : 191523
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy