VIM

(Vimentin)

 

  • Alias                                 (According to NCBI)

 
  • RP11-124N14.1,
  • FLJ36605
  • Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.
  • Location: 10p13
  • Size: 8295 bp
  • exons: 9
  • DNA sequence (Human): NC_000010.9

  • CGH (10p13):  Losses (%) -12.8   Gain (%)  2.8  

  • Mutations and SNPs (According to HGMD and SNP)

 
  • HGMD :
  • SNPs:

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_003380.2

  • Size: 1847 bp

  • cDNA libraries:

  • Size: 466 amino acids: 53652 Da
  • Catalytic activity:

  • Subcellular location:

  • Protein domains

     

  • Protein sequence (Human): P08670

  • Homologous genes:  2538

  • 2D PAGE: VIM

  • 3D Structure:  1GK4 1GK6 1GK7

  • PTM: VIM (One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized.)
  • Pathways and interactions (According to Kegg, IntAct)

 

  • Pathway:  hsa01430  Cell Communication

                        

  • Protein interactions: VIM
  • Clinical                            (According to OMIM, PubMed)