VCAN

(Versican)

 

  • Alias                                 (According to NCBI)

 
  • WGN
  • ERVR
  • PG-M
  • WGN1
  • CSPG2-chondroitin sulfate proteoglycan 2
  • DKFZp686K06110
  • GHAP Glial hyaluronate-binding protein
  • Large fibroblast proteoglycan
  • Versican core protein precursor
  • May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
  • Location: 5q14.3
  • Size:  109399 bp
  • 12 exons
  • DNA sequence (Human):  NC_000005.

  • CGH (5q14.3):  Losses (%) -21.8   Gain (%)  1.7  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:3396 amino acids;  372820 Da
  • Catalytic activity:

  • Subcellular location: Secreted, extracellular space, extracellular matrix.

  • Protein domains

     

  • Pathways and interactions (According to BioCarta, DIP)

  • Protein interactions: vcan
  • Clinical                            (According to OMIM, PubMed)