WISP2

(WNT1 inducible signaling pathway protein 2)

 

  • Alias                                 (According to NCBI)

 

  
  • CCN5,
  • CT58,
  • CTGF-L
  • connective tissue growth factor-like protein;
  • wnt-1 signaling pathway protein 2

 
  • May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.
  • Location: 20q12-q13.1
  • Size: 12568 bp
  • exons: 4
  • DNA sequence (Human): NC_000020.9

  • CGH (20q12):  Losses (%) -2.7   Gain (%)  19.0  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):   NM_003881.2

  • Size: 1433 bp

  • cDNA libraries:

  • Size: 250 amino acids: 26825 Da
  • Catalytic activity:

  • Subcellular location: Secreted

  • Protein domains

     

  • Protein sequence (Human): O76076

  • Homologous genes:  2882

  • 2D PAGE:

  • 3D Structure:  

  • PTM: WISP2

 

 

  • Pathway:

                        

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)