YWHAZ

(tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide)

 

  • Alias                                 (According to NCBI)

 
  • KCIP-1,
  • MGC111427,
  • MGC126532,
  • MGC138156
  • 4-3-3 protein/cytosolic phospholipase A2; 1
  • 4-3-3 zeta;
  • phospholipase A2; p
  • protein kinase C inhibitor protein-1; t
  • yrosine 3/tryptophan 5 -monooxygenase activation protein,
  • zeta polypeptide

 
  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
  • Location: 8q23.1
  • Size: 34656 bp
  • exons: 4
  • DNA sequence (Human): NC_000008.9

  • CGH (8q23.1):  Losses (%) -0.0   Gain (%)  35.8  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): Tranascript varient 1: NM_003406.2; Transcript varient 2:  NM_145690.1

  • Size: Transcipt varient 1 : 2834; Transcript varient 2: 2876 bp

  • cDNA libraries: YWHAZ
  • Protein                        (According to SwissProt, PDB, dbPTM)
  • Size: 245 amino acids; 27745 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

  • Protein domains

     

 
  • Pathways and interactions (According to Kegg, IntAct)

 

  • Pathway:

            Cell cycle
       Pathogenic Escherichia coli infection - EHEC
       Pathogenic Escherichia coli infection - EPEC

                        

  • Protein interactions: YWHAZ
  • Clinical                            (According to OMIM, PubMed)