Alias (According to NCBI)
- ABC21
- MDR2
- MDR2/3
- MDR3
- PFIC-3
- PFIC3
- PGY3
- ATP-binding cassette, sub-family B (MDR/TAP), member 4
- P glycoprotein 3/multiple drug resistance 3
- P-glycoprotein-3/multiple drug resistance-3
- Multidrug resistance protein 3 (P-glycoprotein 3).
Description
(According to SwissProt)
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile.
- Chromosomal location
(According to NCBI, CGH: progenetix)
- Location:7q21.1
- Orientation: Minus strand
- Size: 75,504 bases
- 32 Exons
- DNA Sequence: NT_007933, NT_079595
- CGH (7q21.1): Losses (%) -2.8 Gain (%) 11.7
- Size:1279 amino acids; 140682 Da
- Sub cellular location: Integral membrane protein
- Protein domains:
- Pathways: Multi-Drug Resistance Factors
- Interactions:
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA) : CAB001716
- OMIM:171060
- PubMed: Early detection Diagnosis Prognosis Therapy