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- ABL
- JTK7
- c-ABL
- p150
- v-abl
- Abelson murine leukemia viral (v-abl) oncogene homolog 1
- proto-oncogene tyrosine-protein kinase ABL1
- v-abl Abelson murine leukemia viral oncogene homolog 1
- Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.1.112) (p150)
(c-ABL).
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The ABL1 proto-oncogene encodes a
cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of
cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl
protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns
ABL1 into an oncogene.The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine
kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for
ABL1.
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- Location: 9q34.1
- Orientation: Plus strand
- Size: 173,353 bases
- 11 Exons
- DNA Sequence:NT_035014
- CGH (9q34.1): Losses (%) -3.4 Gain
(%) 13.4
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- Mutations and SNPs (According to HGMD and SNP)
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- Size:1130 amino acids; 122944 Da
- Sub cellular location: Cytoplasmic
- Catalytic activity: ATP + a protein tyrosine = ADP +
protein tyrosine phosphate
- Protein domains:
- Protein sequence: P00519
- Homologous genes:
ABL-1
- 2D PAGE:
- 3D Structure: ABL-1
- PTM: ABL1
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