ABL1

               (Abelson murine leukemia viral (v-abl) oncogene homolog 1)

  • Alias                                 (According to NCBI)

 
  • ABL
  • JTK7 
  • c-ABL
  • p150 
  • v-abl
  • Abelson murine leukemia viral (v-abl) oncogene homolog 1
  • proto-oncogene tyrosine-protein kinase ABL1
  • v-abl Abelson murine leukemia viral oncogene homolog 1 
  • Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.1.112) (p150) (c-ABL).

  • The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene.The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
  • Location: 9q34.1
  • Orientation: Plus strand
  • Size: 173,353 bases
  • 11 Exons
  • DNA Sequence:NT_035014

                   

  • CGH (9q34.1): Losses (%) -3.4   Gain (%)  13.4
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:1130 amino acids; 122944 Da
  • Sub cellular location: Cytoplasmic
  • Catalytic activity: ATP + a protein tyrosine = ADP + protein tyrosine phosphate
  • Protein domains:

                

                                    

  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)