• Alias                                 (According to NCBI)

• DKFZP434N0250
• PKBG
• PRKBG
• RAC-PK-gamma
• RAC-gamma
• STK-2
• RAC-gamma serine/threonine protein kinase
• protein kinase B gamma
• serine threonine protein kinase, Akt-3
• v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
• RAC-gamma serine/threonine protein kinase (EC 2.7.1.-) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

• Description   

  (According to SwissProt)

• The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1).

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location:1q43-q44
• Orientation: Minus strand
• Size: 355,351 bases
• 13 Exons
• DNA Sequence: NT_004836

      CGH (1q43-q44): Losses (%) -0.6   Gain (%)  12.3

• Mutations and SNPs (According to HGMD and SNP)

• HGMD:
• SNP: AKT3

• m-RNA                       (According to NCBI and CGAP)

• m-RNA Sequence: 2 Transcript variants: NM_005465, NM_181690
• c-DNA Libraries: AKT3

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size:479 amino acids; 55774 Da
• Sub cellular location: Cytoplasmic and membrane a
• ssociated after cell stimulation leading to its translocation.
• Protein domains:
       

• Protein sequence: Q9Y243
• Homologous genes: AKT3
• 2D PAGE:
• 3D Structure:
• PTM: AKT3

• Pathways and interactions (According to BioCarta, DIP)

• Pathways:
• Apoptosis
• MAPK signaling pathway
• Sphingoglycolipid metabolism
• Inositol phosphate metabolism
• Starch and sucrose metabolism
• Integrin-mediated cell adhesion
• Porphyrin and chlorophyll metabolism
• Toll-like receptor signaling pathway
• Benzoate degradation via CoA ligation
• Nicotinate and nicotinamide metabolism
• Interactions:

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas: CAB013090

• Clinical                            (According to OMIM, PubMed)

• OMIM:
• PubMed: Early detection        Diagnosis        Prognosis        Therapy