ALDH8

                      (aldehyde dehydrogenase 8)

  • Alias                                 (According to NCBI)

 
  • ALDH8
  • aldehyde dehydrogenase 3 family, member B2
  • aldehyde dehydrogenase 8
  • Aldehyde dehydrogenase 8 (EC 1.2.1.5).

  • The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Although the gene is highly homologous to closely related family members, an earlier in-frame stop codon suggests several possibilities. It could represent a nonprocessed pseudogene, a functional gene where the premature stop codon is suppressed, or a gene product where a downstream in-frame ATG serves as the initiator codon. The expression of these transcripts is restricted to the salivary gland among the human tissues examined.
  •  Location:11q13
  • Orientation: Minus strand 
  • Size:12,431 bases
  • 10  Exons
  • DNA Sequence: NT_033903

  • CGH (11q13):  Losses (%) -3.4   Gain (%)  34.1
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 

 
  • Size: 385 amino acids; 42795 Da
  • Catalytic activity: An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H
  • Protein domains:
     

           

  • Pathways and interactions (According to BioCarta, DIP)

 
  • Clinical                            (According to OMIM, PubMed)